* The Sheltering Sky (1949)
* Edderkoppens hus (1955)
* Anerkendelserne (1955)
* Augustin (1956)
* Terningemanden (1971)
* Gravity's Rainbow (1973)
* Time's Arrow (1990)
* Mason &Dixon (1997)
* Mod dagen (2006)
* The System of the World (2006)
* Underverden (1997)
Noveller:
* "Raketmanden" (1946)
* "Zone" (1947)
* "Sømanden der faldt fra nåde med havet" (1956)
* "Driblet" (1957)
* "The Real Thing" (1983)
* "Beyond the Zero" (1985)
* "Scurrying Fuzzy" (1986)
* "Entropy" (1990)
* "Vineland" (1994)
Faglitteratur:
* The Crying of Lot 49 (1966)
* White Noise (1985)
* Underverden (1997)
* Don DeLillo om Amerika (2003)
* The Body Artist (2001)
* Falling Man (2007)
* Point Omega (2010)
* Englen Esmeralda (2011)
* Zero K (2016)