- Homer Simpson
- Marge Simpson
- Bart Simpson
- Lisa Simpson
- Maggie Simpson
Andre bemærkelsesværdige Simpsons-karakterer:
- Abraham "Grampa" Simpson
- Jacqueline "Jackie" Bouvier
- Waylon Smithers
- Milhouse Van Houten
- Nelson Muntz
- Ralph Wiggum
- Martin Prins
- Todd Flanders
- Rod Flanders
- Maude Flandern
- Ned Flanders
- Edna Krabappel
- Seymour Skinner
- Chef Wiggum
- Sideshow Bob
- Kang og Kodos
- Moe Szyslak
- Lenny Leonard
- Carl Carlson
- Kent Brockman
- Lionel Hutz
- Troy McClure
- Hans Moleman
- Disco Stu
- Skør kattedame
- Pastor Lovejoy
- Mr. Burns
- Waylon Smithers
- Fede Tony
- Legitime forretningsmand